SCHEMBL11565149

SCHEMBL11565149

O=C(Cn1ccnn1)Nc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.50
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
SCN1A P35498 1/20 0.49
SCN2A Q99250 1/20 0.49
SCN3A Q9NY46 1/20 0.49
CYP19A1 P11511 4/20 0.48
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
GAA P10253 1/20 0.47
ALDH1A1 P00352 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11542040 0.79 GLS (0.52) TP53MEN1KMT2ASCN1ASCN2A
SCHEMBL11448976 0.78 TP53 (0.74) TP53MEN1KMT2AGAAALDH1A1
SCHEMBL6763673 0.76 CYP19A1 (0.59) CYP19A1GAAALDH1A1CYP1A1RAB9A
SCHEMBL12503738 0.73 GAA (0.39) CYP19A1HDAC1GAACYP1A1
SCHEMBL2825206 0.73 FOLH1 (0.38) CYP19A1ALDH1A1NPC1KDM4ECYP1A1
SCHEMBL11181159 0.73 ALDH1A1 (0.72) TP53MEN1KMT2ASCN1ASCN2A
SCHEMBL16230975 0.73 TSHR (0.55) MEN1KMT2ACYP19A1GAAALDH1A1
SCHEMBL6289489 0.72 TAAR1 (0.44) TP53GAAALDH1A1NPC1KDM4E
SCHEMBL21076446 0.72 MGLL (0.62) CYP19A1ALDH1A1KDM4ENPSR1
SCHEMBL23774505 0.72 PDE4B (0.57) MEN1KMT2ACYP19A1HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0000539-A1 Copper complexes of N-pyrazole, N-imidazole and N-triazole acetanilides, their preparation and their use as fungicides CIBA-GEIGY AG (CH) 1979-02-07 EP disclosed