Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.54 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2985624 | 0.91 | NPFFR1 (0.62) | FAAHOPRM1OPRD1OPRK1NPFFR1 | |
| SCHEMBL5556286 | 0.90 | ALDH1A1 (0.61) | FAAHOPRM1OPRD1OPRK1NPFFR1 | |
| SCHEMBL6045494 | 0.89 | NPFFR1 (0.61) | FAAHOPRM1OPRD1OPRK1NPFFR1 | |
| Hydrochloric Acid SCHEMBL11455282 | 0.89 | NPFFR1 (0.61) | FAAHOPRM1OPRD1OPRK1NPFFR1 | |
| Hydrochloric Acid SCHEMBL5240984 | 0.89 | NPFFR1 (0.61) | FAAHOPRM1OPRD1OPRK1NPFFR1 | |
| SCHEMBL11566839 | 0.88 | OPRM1 (0.53) | FAAHOPRM1OPRD1OPRK1NPFFR1 | |
| SCHEMBL11564776 | 0.88 | CA12 (0.55) | OPRM1NPFFR1NPFFR2SIGMAR1TMEM97 | |
| SCHEMBL11567112 | 0.87 | FAAH (0.55) | FAAHOPRM1OPRD1OPRK1NPFFR1 | |
| SCHEMBL11563209 | 0.85 | OPRM1 (0.55) | OPRM1OPRD1OPRK1NPFFR1NPFFR2 | |
| Hydrochloric Acid SCHEMBL11566542 | 0.84 | OPRM1 (0.54) | OPRM1OPRD1OPRK1NPFFR1NPFFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1081635-C | Substituted pyrrolidin-3-Yl-alkyl-piperidines useful as tachykinin antagonists | MERRELL DOW PHARMA (US) | 2002-03-27 | — | — | CN | disclosed |
| CN-1124961-A | Substituted pyrrolidin-3-Yl-alkyl-piperidines useful as tachykinin antagonists | MERRELL DOW PHARMA (US) | 1996-06-19 | — | — | CN | disclosed |
| US-4179569-A | ANALGESIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |
| US-3998834-A | ANALGESICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-12-21 | — | — | US | disclosed |