Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11568970 | 0.77 | LMNA (0.38) | MAPTMAPK14GAAHPGDSMN1; SMN2 | |
| SCHEMBL11322236 | 0.75 | GCGR (0.35) | GCGRMAPK14 | |
| SCHEMBL4173953 | 0.74 | MDM2 (0.49) | MAPTMEN1KMT2ATP53GPR55 | |
| SCHEMBL2662802 | 0.74 | MAPK14 (0.55) | MAPTMEN1KMT2ATP53MDM2 | |
| SCHEMBL31567897 | 0.73 | AR (0.67) | MAPTMEN1KMT2ATP53GPR55 | |
| SCHEMBL24584761 | 0.71 | NPC1 (0.63) | MAPTMEN1KMT2ATP53GPR55 | |
| Hydrochloric Acid SCHEMBL11452359 | 0.69 | GRM6 (0.53) | MAPTMEN1KMT2ATP53GPR55 | |
| SCHEMBL22730883 | 0.69 | ALDH1A1 (0.60) | MAPTMEN1KMT2ATP53GPR55 | |
| SCHEMBL31567904 | 0.68 | ALDH1A1 (0.62) | MAPTMEN1KMT2ATP53MDM2 | |
| SCHEMBL31567905 | 0.68 | ALDH1A1 (0.62) | MAPTMEN1KMT2ATP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005156-A1 | 4,5-diaryl-2-(substituted-thio)-pyrroles and their corresponding sulfoxides and sulfones, process for their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-11-14 | — | — | EP | disclosed |