SCHEMBL11567403

C[C@@H](NC(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1)C(=O)NCC(=O)N(C(=O)OC(C)(C)C)[C@@](C)(Cc1ccccc1)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	OPRD1	P41143	7/20	0.47

▸	OPRM1	P35372	4/20	0.47

▸	OPRK1	P41145	1/20	0.47

▸	PSMB1	P20618	3/20	0.46

▸	PSMB9	P28065	2/20	0.46

▸	PSMB5	P28074	2/20	0.46

▸	PSMB10	P40306	2/20	0.46

▸	PSMB2	P49721	2/20	0.46

▸	REN	P00797	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL11569674	0.92	OPRD1 (0.56)	OPRD1OPRM1OPRK1
SCHEMBL11350815	0.81	OPRD1 (0.52)	OPRD1OPRM1OPRK1PSMB1PSMB9
SCHEMBL11525882	0.80	OPRD1 (0.59)	OPRD1OPRM1OPRK1PSMB1PSMB9
SCHEMBL11569802	0.76	PSMB10 (0.46)	PSMB1PSMB9PSMB5PSMB10PSMB2
SCHEMBL11349856	0.76	LTA4H (0.51)	PSMB1PSMB9PSMB5PSMB10PSMB2
SCHEMBL11349836	0.76	LTA4H (0.45)	PSMB1PSMB9PSMB5PSMB10PSMB2
SCHEMBL11760152	0.75	LNPEP (0.59)	PSMB1PSMB9PSMB5PSMB10PSMB2
SCHEMBL11566754	0.74	PSMB1 (0.61)	PSMB1PSMB9PSMB5PSMB10PSMB2
SCHEMBL11377475	0.74	OPRD1 (0.59)	OPRD1OPRM1OPRK1
SCHEMBL30631019	0.74	PSMB1 (0.61)	OPRD1OPRM1OPRK1PSMB1PSMB9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0001684-A2	Tetrapeptides, methods for their preparation and their use in analgesic compositions	ELI LILLY AND COMPANY (US)	1979-05-02	—	—	EP	disclosed