Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11563512 | 0.82 | USP8 (0.38) | ALDH1A1KDM4ESMN1; SMN2CYP2C9LMNA | |
| SCHEMBL11565243 | 0.74 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2CYP2C9LMNA | |
| SCHEMBL11564349 | 0.71 | HSD17B10 (0.48) | ALDH1A1KDM4ESMN1; SMN2CYP2C9LMNA | |
| SCHEMBL11083395 | 0.69 | MEN1 (0.56) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL295307 | 0.68 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2CYP2C9LMNA | |
| SCHEMBL11564415 | 0.68 | USP8 (0.42) | ALDH1A1KDM4ECYP2C9USP8USP7 | |
| SCHEMBL12114202 | 0.67 | ALDH1A1 (0.53) | ALDH1A1KDM4ESMN1; SMN2CYP2C9LMNA | |
| SCHEMBL11560283 | 0.67 | PDE9A (0.41) | ALDH1A1KDM4ECYP2C9GLAGAA | |
| Methane SCHEMBL28696439 | 0.66 | ALDH1A1 (0.47) | ALDH1A1KDM4ESMN1; SMN2CYP2C9LMNA | |
| Methane SCHEMBL4141657 | 0.66 | ALDH1A1 (0.47) | ALDH1A1KDM4ESMN1; SMN2CYP2C9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4180666-A | 3,9-Dihydro-3,9-dioxo-2H-indeno(2,1-c)-pyridine-4-(carbonitriles/carboxamides) | G. D. SEARLE & CO. (US) | 1979-12-25 | — | — | US | disclosed |