Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11565243 | 0.81 | ALDH1A1 (0.44) | HSD17B10ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10949178 | 0.74 | MAOB (0.44) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL6824878 | 0.71 | MEN1 (0.67) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL11567837 | 0.71 | ALDH1A1 (0.48) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL9148849 | 0.70 | NR4A1 (0.52) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL9158144 | 0.69 | ALDH1A1 (0.54) | HSD17B10ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL11564514 | 0.69 | HSD11B1 (0.56) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL11462985 | 0.68 | ALDH1A1 (0.59) | HSD17B10ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30662020 | 0.68 | ALDH1A1 (0.68) | HSD17B10ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11562611 | 0.68 | GRIA2 (0.37) | ALDH1A1CYP1A2CYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4180666-A | 3,9-Dihydro-3,9-dioxo-2H-indeno(2,1-c)-pyridine-4-(carbonitriles/carboxamides) | G. D. SEARLE & CO. (US) | 1979-12-25 | — | — | US | claimed |
| US-4180666-A | 3,9-Dihydro-3,9-dioxo-2H-indeno(2,1-c)-pyridine-4-(carbonitriles/carboxamides) | G. D. SEARLE & CO. (US) | 1979-12-25 | — | — | US | disclosed |