Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CCL2 | P13500 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527441 | 0.79 | HTR6 (0.33) | HTR2AHTR6 | |
| SCHEMBL11575783 | 0.76 | HTR6 (0.31) | HTR2AHTR6 | |
| SCHEMBL9056494 | 0.75 | HTR2A (0.38) | HTR2AHTR6BRD4CCL2 | |
| SCHEMBL9568818 | 0.72 | HTR2A (0.32) | HTR2A | |
| SCHEMBL11124550 | 0.71 | HTR2A (0.33) | HTR2A | |
| SCHEMBL29603716 | 0.71 | SIGMAR1 (0.38) | HTR2AHTR6BRD4CCL2 | |
| SCHEMBL8368203 | 0.71 | HTR2A (0.38) | HTR2AHTR6BRD4CCL2 | |
| SCHEMBL29658875 | 0.71 | SIGMAR1 (0.41) | HTR2AHTR6BRD4CCL2 | |
| SCHEMBL6752383 | 0.71 | HTR2A (0.38) | HTR2AHTR6BRD4CCL2 | |
| SCHEMBL668104 | 0.71 | SIGMAR1 (0.38) | HTR2AHTR6BRD4CCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4173633-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1979-11-06 | — | — | US | disclosed |
| US-4172945-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-10-30 | — | — | US | disclosed |
| US-4138497-A | Indanpentol derivatives for treating hypertension | E. R. SQUIBB & SONS, INC. (US) | 1979-02-06 | — | — | US | disclosed |
| US-4127578-A | Diene intermediates for indantetrols | E. R. SQUIBB & SONS, INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4092318-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-4053596-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4044040-A | HYPERTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-08-23 | — | — | US | disclosed |