SCHEMBL11575207

SCHEMBL11575207

CNc1c([N+](=O)[O-])cc(C(C)C)cc1[N+](=O)[O-]

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.44
CYP2C9 P11712 4/20 0.44
CYP2C19 P33261 4/20 0.44
L3MBTL1 Q9Y468 3/20 0.44
ALDH1A1 P00352 3/20 0.44
CYP3A4 P08684 2/20 0.44
POLB P06746 2/20 0.42
GALR2 O43603 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 8/20 0.41
TDP1 Q9NUW8 2/20 0.41
MAPK1 P28482 1/20 0.41
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
HCAR3 P49019 1/20 0.37
HPGD P15428 1/20 0.36
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36
ALOX15 P16050 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11574717 0.83 CYP1A2 (0.50) CYP1A2CYP2C9CYP2C19L3MBTL1ALDH1A1
SCHEMBL3305172 0.78 MAPT (0.51) CYP1A2CYP2C9L3MBTL1ALDH1A1CYP3A4
SCHEMBL5201446 0.78 TDP1 (0.50) CYP1A2CYP2C9CYP2C19L3MBTL1ALDH1A1
SCHEMBL30613334 0.78 MAPT (0.51) CYP1A2CYP2C9L3MBTL1ALDH1A1CYP3A4
SCHEMBL11800210 0.78 TSHR (0.39) CYP1A2CYP2C9CYP2C19L3MBTL1ALDH1A1
SCHEMBL9501864 0.78 GPR35 (0.57) CYP1A2CYP2C9CYP2C19L3MBTL1ALDH1A1
SCHEMBL14410276 0.77 HCAR3 (0.55) CYP1A2CYP2C9CYP2C19ALDH1A1MAPT
SCHEMBL5078794 0.76 GPR35 (0.61) CYP1A2CYP2C9ALDH1A1MAPTTDP1
SCHEMBL10797402 0.76 TSHR (0.50) CYP1A2CYP2C9CYP2C19ALDH1A1CYP3A4
SCHEMBL3284881 0.76 LMNA (0.44) CYP1A2CYP2C9CYP2C19L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4077795-A 2,4-DINITROANILINE DERIVATIVES UNION CARBIDE CORPORATION (US) 1978-03-07 US disclosed