SCHEMBL11575657

SCHEMBL11575657

CCOC(=O)N1CCN(C2Cc3ccc(OC)cc3Oc3ccc(C)cc32)CC1

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
MTNR1B P49286 12/20 0.46
MTNR1A P48039 5/20 0.44
GAA P10253 3/20 0.44
KDM4E B2RXH2 1/20 0.44
TSHR P16473 1/20 0.44
HSD17B10 Q99714 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
ALOX12 P18054 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
POLB P06746 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11599293 0.89 POLB (0.49) ALDH1A1MTNR1BMTNR1AGAAKDM4E
SCHEMBL11578022 0.87 ALDH1A1 (0.53) ALDH1A1GAAL3MBTL1ALOX12SMN1; SMN2
SCHEMBL11576248 0.85 HRH3 (0.42) MTNR1B
SCHEMBL11577388 0.82 MAOB (0.38) ALDH1A1MTNR1BMTNR1A
Hydrochloric Acid SCHEMBL11577946 0.81 MAOB (0.37) ALDH1A1MTNR1BMTNR1A
SCHEMBL11575922 0.81 HTR3A (0.41)
SCHEMBL11578485 0.80 ALDH1A1 (0.48) ALDH1A1GAAKDM4EL3MBTL1ALOX12
SCHEMBL11575385 0.77 ALDH1A1 (0.47) ALDH1A1GAAKDM4ETSHRSMN1; SMN2
SCHEMBL11576273 0.77 NQO2 (0.40) ALDH1A1GAAPOLB
SCHEMBL8650255 0.75 MTNR1B (0.78) ALDH1A1MTNR1BMTNR1AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4118572-A CNS DEPRESSANTS, NEUROLEPTIC AGENTS, SCHIZOPHRENIA, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-10-03 US disclosed
US-4100173-A DEPRESSANTS, SCHIZOPHRENIA, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-07-11 US disclosed
US-4091023-A ANTISCHIZOPHRENIA AGENTS, TRANQUILIZERS HOFFMANN-LA ROCHE INC. (US) 1978-05-23 US disclosed
US-4032525-A CNS DEPRESSANTS, NEUROLEPTICS HOFFMANN-LA ROCHE INC. (US) 1977-06-28 US disclosed