Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 12/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10836056 | 0.93 | VCAM1 (0.50) | VCAM1TDP1TSHRMAPK1NPBWR1 | |
| SCHEMBL28937850 | 0.92 | VCAM1 (0.49) | VCAM1TDP1TSHRMAPK1NPBWR1 | |
| SCHEMBL7761074 | 0.84 | TSHR (0.58) | VCAM1TDP1TSHRMAPK1 | |
| SCHEMBL12142799 | 0.80 | VCAM1 (0.51) | VCAM1TDP1TSHRMAPK1NPBWR1 | |
| SCHEMBL1858467 | 0.76 | ALDH1A1 (0.56) | VCAM1TDP1TSHRMAPK1 | |
| SCHEMBL6651702 | 0.76 | TSHR (0.55) | TDP1TSHRMAPK1 | |
| SCHEMBL14733275 | 0.76 | MAPT (0.59) | TSHRMAPK1 | |
| SCHEMBL541080 | 0.73 | VCAM1 (0.59) | VCAM1TDP1TSHRMAPK1NPBWR1 | |
| SCHEMBL16914501 | 0.73 | MAPT (0.51) | TDP1TSHR | |
| SCHEMBL5992360 | 0.72 | VCAM1 (0.60) | VCAM1TDP1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4127670-A | ANTHELMINTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-11-28 | — | — | US | disclosed |