Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | TEAD4 | Q15561 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3558568 | 0.82 | KDM4E (0.65) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL4526286 | 0.79 | KDM4E (0.53) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL13078827 | 0.79 | KDM4E (0.53) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL3555239 | 0.76 | KDM4E (0.54) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL11332652 | 0.76 | KDM4E (0.50) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL622814 | 0.76 | KDM4E (0.50) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL6786876 | 0.76 | KDM4E (0.50) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL18120558 | 0.76 | KDM4E (0.66) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL13395932 | 0.73 | KDM4E (0.51) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL21173510 | 0.73 | KDM4E (0.59) | KDM4EPOLBALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119161317-A | Vinyl pyrone compound and application thereof | 福建医科大学 | 2024-12-20 | — | — | CN | disclosed |
| US-8222279-B2 | Small molecule insulin mimetics absent quinones | DUKE UNIVERSITY (US) | 2012-07-17 | — | — | US | disclosed |
| US-8222279-B2 | Small molecule insulin mimetics absent quinones | DUKE UNIVERSITY (US) | 2012-07-17 | — | — | US | disclosed |
| US-8222279-B2 | Small molecule insulin mimetics absent quinones | DUKE UNIVERSITY (US) | 2012-07-17 | — | — | US | disclosed |
| US-8188144-B2 | In vitro preservation of living animal cells and compounds suitable for use in the preservation of living animal cells | ANTOXIS LIMITED (GB) | 2012-05-29 | — | — | US | disclosed |
| US-8188144-B2 | In vitro preservation of living animal cells and compounds suitable for use in the preservation of living animal cells | ANTOXIS LIMITED (GB) | 2012-05-29 | — | — | US | disclosed |
| US-20110028519-A1 | SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES | PIRRUNG MICHAEL C | 2011-02-03 | — | — | US | disclosed |
| US-20110028519-A1 | SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES | PIRRUNG MICHAEL C | 2011-02-03 | — | — | US | disclosed |
| US-20110028519-A1 | SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES | PIRRUNG MICHAEL C | 2011-02-03 | — | — | US | disclosed |
| US-7834050-B2 | Use of indole compounds such as 3-Hydroxy-6-hydroxymethyl-1-methyl-2-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-pyridin-4-one | DUKE UNIVERSITY (US) | 2010-11-16 | — | — | US | disclosed |
| US-7834050-B2 | Use of indole compounds such as 3-Hydroxy-6-hydroxymethyl-1-methyl-2-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-pyridin-4-one | DUKE UNIVERSITY (US) | 2010-11-16 | — | — | US | disclosed |
| US-7834050-B2 | Use of indole compounds such as 3-Hydroxy-6-hydroxymethyl-1-methyl-2-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-pyridin-4-one | DUKE UNIVERSITY (US) | 2010-11-16 | — | — | US | disclosed |
| US-20100267132-A1 | IN VITRO PRESERVATION OF LIVING ANIMAL CELLS AND COMPOUNDS SUITABLE FOR USE IN THE PRESERVATION OF LIVING ANIMAL CELLS | ANTOXIS LIMITED (GB) | 2010-10-21 | — | — | US | disclosed |
| US-20100267132-A1 | IN VITRO PRESERVATION OF LIVING ANIMAL CELLS AND COMPOUNDS SUITABLE FOR USE IN THE PRESERVATION OF LIVING ANIMAL CELLS | ANTOXIS LIMITED (GB) | 2010-10-21 | — | — | US | disclosed |
| US-20070232663-A1 | SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
| US-20070232663-A1 | SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
| US-20070232663-A1 | SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028519-A1 | SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES | IAPP, GPR119, IRS1 | KDM4E 3960/4885POLB 1766/4885ALDH1A1 1176/4885 |
| US-20100267132-A1 | IN VITRO PRESERVATION OF LIVING ANIMAL CELLS AND COMPOUNDS SUITABLE FOR USE IN THE PRESERVATION OF LIVING ANIMAL CELLS | PIGS, AQP1, F12 | KDM4E 1441/4885POLB 2624/4885ALDH1A1 4/4885 |
| US-20070232663-A1 | SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES | IAPP, GPR119, IRS1 | KDM4E 3960/4885POLB 1766/4885ALDH1A1 1176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.