Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | CNR1 | P21554 | 2/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.57 |
| ▸ | USP2 | O75604 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | AR | P10275 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | IL6 | P05231 | 1/20 | 0.54 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11586807 | 0.94 | PGR (0.64) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11586806 | 0.94 | PGR (0.64) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11585564 | 0.91 | PGR (0.61) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11585566 | 0.91 | PGR (0.61) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11586335 | 0.91 | NR3C1 (0.66) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11586331 | 0.91 | NR3C1 (0.66) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11230636 | 0.89 | NR3C1 (0.65) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL23892577 | 0.89 | NR3C1 (0.73) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL19393185 | 0.89 | NR3C1 (0.73) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11045196 | 0.89 | NR3C1 (0.73) | PGRHIF1ANR3C1LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | disclosed |