Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 14/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11585564 | 1.00 | PGR (0.61) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11583983 | 0.91 | NR3C1 (0.67) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11583987 | 0.91 | NR3C1 (0.67) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11584989 | 0.91 | PGR (0.68) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11365692 | 0.91 | PGR (0.59) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11580265 | 0.90 | NR3C1 (0.60) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11581859 | 0.90 | NR3C1 (0.60) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11586806 | 0.88 | PGR (0.64) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11586807 | 0.88 | PGR (0.64) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11122309 | 0.86 | ABCB11 (0.71) | PGRHIF1ANR3C1LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | disclosed |