Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | CNR1 | P21554 | 3/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | IL6 | P05231 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11586807 | 1.00 | PGR (0.64) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11584989 | 0.94 | PGR (0.68) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11795449 | 0.92 | PGR (0.54) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11795442 | 0.92 | PGR (0.54) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL4215930 | 0.89 | NR3C1 (0.62) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11585566 | 0.88 | PGR (0.61) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11585564 | 0.88 | PGR (0.61) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11296376 | 0.87 | NR3C1 (0.63) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11789314 | 0.86 | NR3C1 (0.52) | PGRHIF1ANR3C1LMNACNR1 | |
| SCHEMBL11789320 | 0.86 | NR3C1 (0.52) | PGRHIF1ANR3C1LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | disclosed |