Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358576 | 0.91 | ZAP70 (0.40) | SYKZAP70BRD4 | |
| SCHEMBL3361975 | 0.90 | KDR (0.38) | SYKZAP70JAK2 | |
| SCHEMBL3359250 | 0.89 | ZAP70 (0.53) | SYKZAP70WEE1JAK2TBK1 | |
| SCHEMBL3360687 | 0.89 | ZAP70 (0.47) | ZAP70BRD4 | |
| SCHEMBL3357832 | 0.83 | ZAP70 (0.42) | SYKZAP70WEE1 | |
| SCHEMBL1159549 | 0.82 | ZAP70 (0.40) | SYKZAP70WEE1JAK2 | |
| SCHEMBL3358792 | 0.82 | ZAP70 (0.42) | SYKZAP70WEE1JAK2TBK1 | |
| SCHEMBL3360946 | 0.82 | ZAP70 (0.51) | SYKZAP70WEE1TBK1BRD4 | |
| SCHEMBL3362296 | 0.81 | ZAP70 (0.49) | ZAP70BRD4 | |
| SCHEMBL3360152 | 0.81 | ZAP70 (0.64) | SYKZAP70WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |