Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.51 |
| ▸ | WEE1 | P30291 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360152 | 0.89 | ZAP70 (0.64) | ZAP70WEE1SYK | |
| SCHEMBL3360818 | 0.84 | SYK (0.42) | ZAP70PIK3CASYKMTOR | |
| SCHEMBL3361273 | 0.82 | SYK (0.43) | ZAP70WEE1SYKBRD4TBK1 | |
| SCHEMBL3357921 | 0.81 | ZAP70 (0.47) | ZAP70PIK3CAMTORBRD4 | |
| SCHEMBL3359250 | 0.81 | ZAP70 (0.53) | ZAP70WEE1SYKBRD4TBK1 | |
| SCHEMBL3357832 | 0.81 | ZAP70 (0.42) | ZAP70WEE1SYK | |
| SCHEMBL3359784 | 0.81 | ZAP70 (0.51) | ZAP70WEE1SYK | |
| SCHEMBL3363341 | 0.80 | SYK (0.41) | ZAP70PIK3CASYKMTOR | |
| SCHEMBL3362713 | 0.80 | ZAP70 (0.56) | ZAP70PIK3CASYKMTOR | |
| SCHEMBL1160077 | 0.80 | ZAP70 (0.44) | ZAP70WEE1BRD4ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |