Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 4/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 7/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968707 | 0.78 | HSD11B1 (0.38) | GABRG2GABRB3GABRA1GABRA2PDE4B | |
| SCHEMBL1042919 | 0.76 | DCTPP1 (0.44) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL30955913 | 0.72 | MKNK1 (0.35) | KDM4DPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2750732 | 0.72 | BRD4 (0.54) | SMN1; SMN2TSHRALDH1A1LMNAHPGD | |
| SCHEMBL4089296 | 0.70 | SLC6A2 (0.36) | GABRG2GABRB3GABRA1METESR2 | |
| SCHEMBL5801474 | 0.67 | MKNK1 (0.53) | SMN1; SMN2TSHRALDH1A1HPGDMAPK1 | |
| SCHEMBL16417549 | 0.65 | SMN1; SMN2 (0.41) | GABRG2GABRB3GABRA1GABRA2SMN1; SMN2 | |
| SCHEMBL29412287 | 0.65 | ESR2 (0.60) | GABRG2GABRB3ESR2GABRA5GABRA3 | |
| SCHEMBL222 | 0.65 | ESR2 (0.60) | GABRG2GABRB3ESR2GABRA5GABRA3 | |
| SCHEMBL10809503 | 0.65 | MET (0.48) | GABRG2GABRB3METESR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011014462-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2011-02-03 | — | — | WO | disclosed |