Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 8/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363341 | 0.89 | SYK (0.41) | ZAP70SYKWNT3ACSF1RCCNK | |
| SCHEMBL3363030 | 0.89 | ZAP70 (0.39) | ZAP70SYKPDE10A | |
| SCHEMBL3356474 | 0.87 | ZAP70 (0.37) | ZAP70SYKWNT3ACSF1RCDK4 | |
| SCHEMBL3359250 | 0.86 | ZAP70 (0.53) | ZAP70SYK | |
| SCHEMBL3361858 | 0.86 | ZAP70 (0.47) | ZAP70SYKCSF1RCCNKCDK4 | |
| SCHEMBL3359095 | 0.85 | ZAP70 (0.45) | ZAP70SYKCCNA2CDK2KDR | |
| SCHEMBL1159575 | 0.82 | ZAP70 (0.49) | ZAP70SYK | |
| SCHEMBL3362296 | 0.82 | ZAP70 (0.49) | ZAP70 | |
| SCHEMBL3361376 | 0.81 | ZAP70 (0.42) | ZAP70 | |
| SCHEMBL3363125 | 0.81 | ZAP70 (0.49) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |