Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.82 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL28630445 | 0.91 | — | — | |
| Glycerin SCHEMBL28630443 | 0.91 | — | — | |
| Glycerin SCHEMBL19656174 | 0.91 | — | — | |
| Glycerin SCHEMBL1678248 | 0.91 | — | — | |
| Glycerin SCHEMBL19689532 | 0.91 | — | — | |
| Glycerin SCHEMBL28835091 | 0.91 | — | — | |
| Glycerin SCHEMBL5031257 | 0.91 | LMNA (0.82) | LMNAALDH1A1THRBTDP1L3MBTL1 | |
| Glycerin SCHEMBL10696736 | 0.91 | — | — | |
| Glycerin SCHEMBL11659325 | 0.91 | LMNA (0.82) | LMNAALDH1A1THRBTDP1L3MBTL1 | |
| Glycerin SCHEMBL19125718 | 0.91 | LMNA (0.82) | LMNAALDH1A1THRBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115554278-A | Flurbiprofen gel plaster with high viscosity and good air permeability and preparation method thereof | 湖北兵兵药业(集团)有限公司 | 2023-01-03 | — | — | CN | claimed |
| CN-110179961-B | Pharmaceutical composition, preparation method and application thereof | 首都医科大学附属北京中医医院 | 2021-11-19 | — | — | CN | claimed |
| CN-218741882-U | Glycerol aluminum hydroxide circulating feeding reaction kettle | 仁和堂药业有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-115554278-A | Flurbiprofen gel plaster with high viscosity and good air permeability and preparation method thereof | 湖北兵兵药业(集团)有限公司 | 2023-01-03 | — | — | CN | disclosed |
| US-4101652-A | Pharmaceutically active complexes and pharmaceutical compositions containing eascin and sterols | INVERNI DELLA BEFFA S.P.A. (IT) | 1978-07-18 | — | — | US | disclosed |