Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propomocarb. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propomocarb SCHEMBL21077 | 0.89 | ACHE (0.61) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL11599265 | 0.88 | ACHE (0.53) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL1724451 | 0.88 | ACHE (0.56) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL11597864 | 0.88 | ACHE (0.56) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL8437517 | 0.88 | ACHE (0.59) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL17095085 | 0.88 | ACHE (0.59) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL68988 | 0.88 | ACHE (0.59) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL11598946 | 0.87 | ACHE (0.54) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL28227333 | 0.86 | ACHE (0.62) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Propomocarb SCHEMBL6552410 | 0.85 | ACHE (0.56) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4108885-A | Salts of thiocarbamic esters with fungicidal and fungistatic action | SCHERING AG (DE) | 1978-08-22 | — | — | US | disclosed |