Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Propomocarb. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 known ✓ | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 known ✓ | P32297 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 14/20 | 0.56 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propomocarb SCHEMBL21077 | 0.95 | ACHE (0.61) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL11597864 | 0.94 | ACHE (0.56) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL17095085 | 0.93 | ACHE (0.59) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL68988 | 0.93 | ACHE (0.59) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL8437517 | 0.93 | ACHE (0.59) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL11598946 | 0.92 | ACHE (0.54) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL28227333 | 0.92 | ACHE (0.62) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL11599265 | 0.91 | ACHE (0.53) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL6552410 | 0.90 | ACHE (0.56) | ACHEDNM1CHRNB2CHRNB4CHRNA3 | |
| Propomocarb SCHEMBL6552413 | 0.90 | ACHE (0.56) | ACHEDNM1CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2540716-B1 | TETRAZOLYLOXIME DERIVATIVE OR A SALT THEREOF, AND GERMICIDE | NIPPON SODA CO (JP) | 2015-11-11 | — | — | EP | disclosed |
| US-9156816-B2 | Tetrazolyloxime derivative or salt thereof and fungicide | NIPPON SODA CO., LTD. (JP) | 2015-10-13 | — | — | US | disclosed |
| EP-2177519-B1 | TETRAZOYLOXIME DERIVATIVE AND PLANT DISEASE CONTROL AGENT | NIPPON SODA CO (JP) | 2015-05-27 | — | — | EP | disclosed |
| US-9029552-B2 | Tetrazoyloxime derivative and plant disease control agent | NIPPON SODA CO., LTD. (JP) | 2015-05-12 | — | — | US | disclosed |
| US-8710084-B2 | Tetrazolyl oxime derivative, salt thereof, and plant disease control agent | NIPPON SODA CO., LTD. (JP) | 2014-04-29 | — | — | US | disclosed |
| US-20140005385-A1 | TETRAZOYLOXIME DERIVATIVE AND PLANT DISEASE CONTROL AGENT | NIPPON SODA CO., LTD. (JP) | 2014-01-02 | — | — | US | disclosed |
| EP-2669282-A1 | Tetrazoyloxime derivative and plant disease control agent | NIPPON SODA CO., LTD. (JP) | 2013-12-04 | — | — | EP | disclosed |
| EP-2404917-B1 | TETRAZOLYL OXIME DERIVATIVE, SALT THEREOF, AND PLANT DISEASE CONTROL AGENT | NIPPON SODA CO (JP) | 2013-09-04 | — | — | EP | disclosed |
| EP-2540716-A1 | TETRAZOLYLOXIME DERIVATIVE OR A SALT THEREOF, AND GERMICIDE | Nippon Soda Co., Ltd. (JP) | 2013-01-02 | — | — | EP | disclosed |
| US-20120309972-A1 | TETRAZOLYLOXIME DERIVATIVE OR SALT THEREOF AND FUNGICIDE | NIPPON SODA CO., LTD. (JP) | 2012-12-06 | — | — | US | disclosed |
| EP-2404917-A1 | TETRAZOYL OXIME DERIVATIVE, SALT THEREOF, AND PLANT DISEASE CONTROL AGENT | Nippon Soda Co., Ltd. (JP) | 2012-01-11 | — | — | EP | disclosed |
| US-20110313152-A1 | TETRAZOLYL OXIME DERIVATIVE, SALT THEREOF, AND PLANT DISEASE | NIPPON SODA CO., LTD. (JP) | 2011-12-22 | — | — | US | disclosed |
| US-20100137594-A1 | TETRAZOYLOXIME DERIVATIVE AND PLANT DISEASE CONTROL AGENT | NIPPON SODA CO., LTD. (JP) | 2010-06-03 | — | — | US | disclosed |
| EP-2177519-A1 | TETRAZOYLOXIME DERIVATIVE AND PLANT DISEASE CONTROL AGENT | Nippon Soda Co., Ltd. (JP) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309972-A1 | TETRAZOLYLOXIME DERIVATIVE OR SALT THEREOF AND FUNGICIDE | AS3MT, PRXL2A, TH | CHRNB4 4527/4885CHRNA3 4394/4885ACHE 3666/4885 |
| US-20110313152-A1 | TETRAZOLYL OXIME DERIVATIVE, SALT THEREOF, AND PLANT DISEASE | H1-10, H1-0, OXSR1 | CHRNB4 3700/4885CHRNA3 2445/4885ACHE 3106/4885 |
| US-20140005385-A1 | TETRAZOYLOXIME DERIVATIVE AND PLANT DISEASE CONTROL AGENT | PAOX, BROX, TTI2 | CHRNB4 4779/4885CHRNA3 4742/4885ACHE 1398/4885 |
| US-20100137594-A1 | TETRAZOYLOXIME DERIVATIVE AND PLANT DISEASE CONTROL AGENT | PAOX, H1-10, HAX1 | CHRNB4 3937/4885CHRNA3 3512/4885ACHE 2082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.