Bromide

Bromide

SCHEMBL11599708

COC(=O)c1ccc(C(=O)OC)c(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-]

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 11/20 0.49
ALDH1A1 P00352 10/20 0.49
HPGD P15428 4/20 0.49
MAPT P10636 4/20 0.49
HSD17B10 Q99714 4/20 0.47
KMT2A Q03164 2/20 0.47
ATM Q13315 3/20 0.47
GLA P06280 2/20 0.47
GAA P10253 2/20 0.47
CASP1 P29466 1/20 0.47
CASP7 P55210 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.45
TSHR P16473 2/20 0.44
LMNA P02545 4/20 0.43
MEN1 O00255 1/20 0.43
SLC7A5 Q01650 1/20 0.42
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL7902023 0.86 CA1 (0.50) KDM4EALDH1A1HPGDMAPTHSD17B10
Bromide SCHEMBL7841361 0.85 ALDH1A1 (0.45) KDM4EALDH1A1HPGDHSD17B10KMT2A
Bromide SCHEMBL17714307 0.85 ABL1 (0.48) KDM4EALDH1A1HSD17B10KMT2AGAA
Bromide SCHEMBL17714327 0.85 PLA2G2A (0.46) KDM4EALDH1A1HPGDMAPTSMN1; SMN2
Bromide SCHEMBL8901631 0.85 PPARG (0.43) ALDH1A1MAPTKMT2ASMN1; SMN2TSHR
Bromide SCHEMBL3558232 0.84 ALDH1A1 (0.53) KDM4EALDH1A1MAPTHSD17B10KMT2A
Hydrochloric Acid SCHEMBL7524637 0.84 CA1 (0.50) KDM4EALDH1A1HPGDMAPTHSD17B10
Bromide SCHEMBL7898722 0.84 XDH (0.50) KDM4EALDH1A1HPGDMAPTHSD17B10
Bromide SCHEMBL10980300 0.83 KDM4E (0.49) KDM4EALDH1A1HPGDMAPTHSD17B10
Bromide SCHEMBL8323844 0.83 DPP4 (0.47) ALDH1A1MAPTKMT2ATSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4112114-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1978-09-05 US disclosed
US-4100174-A Process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids and intermediates SYNTEX (U.S.A.) INC. (US) 1978-07-11 US disclosed
US-4051260-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1977-09-27 US disclosed
US-4041173-A ANTI-ASTHMATIC AGENTS SYNTEX (U.S.A.) INC. (US) 1977-08-09 US disclosed
US-4038299-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1977-07-26 US disclosed
US-4035509-A ANTIALLERGENS SYNTEX (U.S.A.) INC. (US) 1977-07-12 US disclosed
US-4020094-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1977-04-26 US disclosed
US-4011241-A An intermediate in the preparation of 2-(5H-dibenzo[a,d]cyclophepten-5-on-2-yl)acetic, propionic and butyric acids SYNTEX (U.S.A.) INC. (US) 1977-03-08 US disclosed
US-3975540-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1976-08-17 US disclosed
US-3966820-A ANALGESICS, ANTIINFLAMMATORY, ANTIPYRETICS SYNTEX (U.S.A.) INC. (US) 1976-06-29 US disclosed