Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Milrinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 8/20 | 0.77 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.77 |
| ▸ | HPGD | P15428 | 3/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | PDE4A | P27815 | 3/20 | 0.77 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.77 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.77 |
| ▸ | PDE5A | O76074 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | GALR3 | O60755 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Milrinone SCHEMBL8578994 | 0.99 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL1160021 | 0.90 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL36947 | 0.88 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9309054 | 0.88 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9301167 | 0.88 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9247989 | 0.88 | PDE3A (1.00) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9872022 | 0.87 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL28184205 | 0.86 | PDE3A (0.97) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL9132559 | 0.85 | PDE3A (0.94) | PDE3APDE3BHPGDKDM4EPDE4A | |
| Milrinone SCHEMBL3463564 | 0.85 | PDE3A (0.79) | PDE3APDE3BHPGDKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4194361-A1 | INDUCTION HEAT SEAL LINER AND METHOD OF MANUFACTURE | Tekni-Plex, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| US-11414540-B2 | Method for modifying polycarbonate blends | DOW GLOBAL TECHNOLOGIES LLC (ML) | 2022-08-16 | — | — | US | disclosed |
| EP-3914523-A1 | INDUCTION HEAT SEAL LINER AND METHOD OF MANUFACTURE | Tekni-Plex, Inc. (US) | 2021-12-01 | — | — | EP | disclosed |
| US-10968016-B2 | Induction heat seal liner and method of manufacture | TEKNI-PLEX, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-10968017-B2 | Induction heat seal liner and method of manufacture | TEKNI-PLEX, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-20200369868-A1 | METHOD FOR MODIFYING POLYCARBONATE BLENDS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2020-11-26 | — | — | US | disclosed |
| EP-3732250-A1 | METHOD FOR MODIFYING POLYCARBONATE BLENDS | Dow Global Technologies, LLC (US) | 2020-11-04 | — | — | EP | disclosed |
| US-20200277114-A1 | INDUCTION HEAT SEAL LINER AND METHOD OF MANUFACTURE | CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH | 2020-09-03 | — | — | US | disclosed |
| US-20200277113-A1 | INDUCTION HEAT SEAL LINER AND METHOD OF MANUFACTURE | CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH | 2020-09-03 | — | — | US | disclosed |
| CN-102317382-B | Coating composition comprising polymer encapsulated metal oxide opacifying pigment and method of producing the same | DOW GLOBAL TECHNOLOGIES INC | 2015-04-08 | — | — | CN | disclosed |
| WO-2010025013-A1 | METHOD OF CROSSLINKING CARBOXYL-CONTAINING POLYMERS USING OLIGOAMINES | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC (US) | 2010-03-04 | — | — | WO | disclosed |
| US-7247657-B2 | Expandable compositions and methods of making and using the compositions | HENKEL CORPORATION (US) | 2007-07-24 | — | — | US | disclosed |
| US-20050096401-A1 | Expandable compositions and methods of making and using the compositions | ORBSEAL LLC | 2005-05-05 | — | — | US | disclosed |
| US-6830799-B1 | Expandable compositions and methods of making and using the compositions | ORBSEAL LLC | 2004-12-14 | — | — | US | disclosed |
| EP-1230299-A1 | EXPANDABLE COMPOSITIONS AND METHODS OF MAKING AND USING THE COMPOSITIONS | Orbseal LLC (US) | 2002-08-14 | — | — | EP | disclosed |
| EP-1105577-A1 | WEAR-RESISTANT TRANSPORTATION SURFACE MARKING METHOD AND MATERIALS | 3M Innovative Properties Company (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2001030906-A1 | EXPANDABLE COMPOSITIONS AND METHODS OF MAKING AND USING THE COMPOSITIONS | ORBSEAL LLC (US) | 2001-05-03 | — | — | WO | disclosed |
| US-6217252-B1 | Wear-resistant transportation surface marking method and materials | 3M INNOVATIVE PROPERTIES COMPANY | 2001-04-17 | — | — | US | disclosed |
| WO-2000009811-A1 | WEAR-RESISTANT TRANSPORTATION SURFACE MARKING METHOD AND MATERIALS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2000-02-24 | — | — | WO | disclosed |
| US-4756844-A | Controlled-release composition having a membrane comprising submicron particles | THE DOW CHEMICAL COMPANY (US) | 1988-07-12 | — | — | US | disclosed |