Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | P4HB | P07237 | 4/20 | 0.56 |
| ▸ | FBP1 | P09467 | 2/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1687911 | 0.88 | FBP1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| SCHEMBL21574805 | 0.88 | FBP1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| SCHEMBL13799049 | 0.88 | FBP1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| SCHEMBL1260529 | 0.88 | FBP1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| SCHEMBL8699093 | 0.88 | FBP1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| SCHEMBL1687898 | 0.88 | FBP1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| SCHEMBL11384123 | 0.88 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| SCHEMBL992032 | 0.85 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| SCHEMBL992033 | 0.85 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNAL3MBTL1HDAC2 | |
| Bicarbonate SCHEMBL11748879 | 0.85 | CA2 (0.61) | ALDH1A1MAPTLMNAL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4075181-A | POWDER COATING COMPOSITIONS BASED ON A CYCLIC NITRILE COMPOUND | ATLANTIC RICHFIELD COMPANY (US) | 1978-02-21 | — | — | US | disclosed |
| US-4021378-A | POLYURETHANES FROM CYCLIC NITRILE CARBONATE | ATLANTIC RICHFIELD COMPANY (US) | 1977-05-03 | — | — | US | disclosed |
| US-4020023-A | ADIPODI(NITRILE CARBONATE) | ATLANTIC RICHFIELD COMPANY (US) | 1977-04-26 | — | — | US | disclosed |
| US-3960813-A | ADNC BLENDSADIPODI(NITRILE CARBONATE) | ATLANTIC RICHFIELD COMPANY (US) | 1976-06-01 | — | — | US | disclosed |
| US-3932354-A | Stabilization of thermoplastic polyurethanes derived from cyclic nitrile compounds | ATLANTIC RICHFIELD COMPANY (US) | 1976-01-13 | — | — | US | disclosed |
| US-3932361-A | Catalysts for the reaction of cyclic nitrile compounds with nucleophilic compounds | ATLANTIC RICHFIELD COMPANY (US) | 1976-01-13 | — | — | US | disclosed |