Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 8/20 | 0.69 |
| ▸ | ADRA2B known ✓ | P18089 | 8/20 | 0.69 |
| ▸ | ADRA2C known ✓ | P18825 | 8/20 | 0.69 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.69 |
| ▸ | HTR1D known ✓ | P28221 | 4/20 | 0.69 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.69 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.69 |
| ▸ | HTR1B known ✓ | P28222 | 3/20 | 0.69 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.69 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | BLM | P54132 | 3/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | HRH2 | P25021 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10414088 | 0.98 | ADRA2A (0.71) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| SCHEMBL11180812 | 0.85 | ADRA2A (0.76) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| Pi-Clonidine SCHEMBL563884 | 0.82 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| SCHEMBL11761437 | 0.82 | ADRA2C (0.71) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| Apraclonidine SCHEMBL34128 | 0.82 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| Pi-Clonidine SCHEMBL5274141 | 0.81 | LMNA (1.00) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| Apraclonidine SCHEMBL1002875 | 0.81 | BLM (1.00) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| Apraclonidine SCHEMBL1649431 | 0.81 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| Clonidine SCHEMBL9838990 | 0.80 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CADRA1AHTR1D | |
| SCHEMBL6844110 | 0.79 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADRA1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4094964-A | IMMUNOASSAY, HAPTEN, ANTIGEN | HOFFMANN-LA ROCHE INC. (US) | 1978-06-13 | — | — | US | disclosed |