Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11609389 | 0.83 | PTPRC (0.35) | PTPRCKDM4EHPGDHTTTDP1 | |
| SCHEMBL11610183 | 0.72 | ALDH1A1 (0.33) | PTPRCKDM4EHPGDHTTTDP1 | |
| SCHEMBL11613637 | 0.70 | EDNRB (0.41) | PTPRCKDM4EHPGDHTTTDP1 | |
| SCHEMBL11615120 | 0.69 | KDM4E (0.35) | KDM4EHTTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL11610800 | 0.69 | S100A4 (0.32) | KDM4EGAAALDH1A1S100A4 | |
| SCHEMBL11608301 | 0.67 | CYP1A2 (0.40) | EDNRBEDNRAS100A4CYP1A2MAPK1 | |
| SCHEMBL11493735 | 0.66 | CDC25B (0.46) | PTPRCKDM4EHPGDHTTTDP1 | |
| SCHEMBL6904734 | 0.63 | MEN1 (0.52) | PTPRCKDM4EHTTSMN1; SMN2EDNRB | |
| SCHEMBL11675005 | 0.63 | EDNRB (0.40) | PTPRCALDH1A1EDNRBEDNRACYP1A2 | |
| SCHEMBL11491611 | 0.62 | ACHE (0.53) | PTPRCKDM4EHPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3960894-A | 9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones | SANDOZ LTD. (CH) | 1976-06-01 | — | — | US | claimed |
| US-4128549-A | Precursors of 4-(1-alkyl-4-piperidylidene-4H-benzo[4,5]cyclohepta-[1,2-b]thiophen-10(9H)-ones | SANDOZ LTD. (CH) | 1978-12-05 | — | — | US | disclosed |
| US-3960894-A | 9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones | SANDOZ LTD. (CH) | 1976-06-01 | — | — | US | disclosed |