Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11619227 | 0.77 | MAPT (0.53) | HPGDLMNAKMT2AALDH1A1MAPT | |
| SCHEMBL11612842 | 0.77 | KMT2A (0.52) | HPGDLMNAKMT2AALDH1A1NPC1 | |
| SCHEMBL11613669 | 0.72 | NPC1 (0.42) | HPGDLMNAKMT2AALDH1A1NPC1 | |
| SCHEMBL5834552 | 0.70 | SMN1; SMN2 (0.58) | HPGDLMNAKMT2ATDP1L3MBTL1 | |
| SCHEMBL8895204 | 0.69 | L3MBTL1 (0.62) | HPGDLMNAKMT2ATDP1RAB9A | |
| SCHEMBL280618 | 0.68 | LMNA (1.00) | LMNAKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30638434 | 0.68 | LMNA (1.00) | LMNAKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11614313 | 0.68 | NPC1 (0.44) | HPGDLMNAKMT2AALDH1A1NPC1 | |
| SCHEMBL11615915 | 0.68 | KMT2A (0.52) | HPGDLMNAKMT2AALDH1A1TDP1 | |
| SCHEMBL11611800 | 0.68 | PTGDR2 (0.45) | HPGDLMNAKMT2AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |