Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | DBH | P09172 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11619453 | 0.89 | NOX4 (0.43) | DAODBHP2RX7 | |
| SCHEMBL11622380 | 0.85 | ALDH1A1 (0.49) | HTTSMN1; SMN2P2RX7CA12CA1 | |
| SCHEMBL11621895 | 0.85 | HSP90AA1 (0.46) | DAOP2RX7 | |
| SCHEMBL11617928 | 0.84 | SMN1; SMN2 (0.45) | DAOLMNARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11619012 | 0.82 | DAO (0.40) | DAOLMNAHTTSMN1; SMN2IDO1 | |
| SCHEMBL11625554 | 0.79 | PNMT (0.43) | DBHCYP2A13LMNASMN1; SMN2IDO1 | |
| SCHEMBL11623418 | 0.77 | MAPT (0.49) | DAODBHSIGMAR1KDM4E | |
| SCHEMBL11624862 | 0.76 | DAO (0.34) | DAONPC1LMNARAB9A | |
| SCHEMBL11581250 | 0.76 | NPSR1 (0.45) | CYP2A13NPC1LMNAHTTRAB9A | |
| SCHEMBL11624738 | 0.76 | DBH (0.36) | DAODBHIDO1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4076943-A | DIURETICS, SALURETICS, ANTIHYPERTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-02-28 | — | — | US | disclosed |
| US-4061653-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1977-12-06 | — | — | US | disclosed |