SCHEMBL11620342

SCHEMBL11620342

Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccn1)=NC2

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 8/20 0.77
GABRA5 P31644 8/20 0.77
GABRA2 P47869 8/20 0.77
GABRB2 P47870 7/20 0.77
GABRA3 P34903 6/20 0.77
OPRK1 P41145 3/20 0.72
HPGD P15428 3/20 0.72
BRD4 O60885 2/20 0.72
LMNA P02545 2/20 0.72
CNR1 P21554 1/20 0.72
GABRG2 P18507 1/20 0.71
HTR2A P28223 1/20 0.71
GABRB3 P28472 1/20 0.71
ADRA1A P35348 1/20 0.71
PDE4D Q08499 1/20 0.71
SMN1; SMN2 Q16637 2/20 0.66
ALDH1A1 P00352 1/20 0.58
PTAFR P25105 4/20 0.56
TSHR P16473 1/20 0.56
CYP1A2 P05177 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11720129 0.87 GABRA1 (0.59) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL11624016 0.87 GABRA1 (1.00) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL11861962 0.87 TDP1 (0.69) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL29385106 0.87 GABRA1 (1.00) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL11830564 0.86 OPRK1 (0.59) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL11623879 0.85 GABRA1 (0.74) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL19006770 0.84 GABRA1 (0.55) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL7434779 0.84 OPRK1 (0.74) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL11618403 0.84 GABRA1 (0.72) GABRA1GABRA5GABRA2GABRB2GABRA3
SCHEMBL11605914 0.84 GABRA1 (0.58) GABRA1GABRA5GABRA2GABRB2GABRA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4075221-A ALKYLATION WITH DIALKYLMETHYLENEAMMONIUM SALT IN PRESENCE OF REACTIVE CARBOXYLIC ACYLATING AGENT THE UPJOHN COMPANY (US) 1978-02-21 US disclosed
US-4044016-A ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS HOFFMANN-LA ROCHE INC. (US) 1977-08-23 US disclosed
US-3970664-A ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE HOFFMANN-LA ROCHE INC. (US) 1976-07-20 US disclosed
US-3954728-A ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES HOFFMAN-LA ROCHE INC. (US) 1976-05-04 US disclosed