Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 6/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | CYBB | P04839 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805413 | 0.80 | NCF1 (0.76) | NCF1BACE1TLR8CYBBALDH1A1 | |
| SCHEMBL4620763 | 0.78 | PDE10A (0.52) | PDE10AMEN1KMT2AALDH1A1 | |
| SCHEMBL4621639 | 0.76 | PDE10A (0.47) | PDE10AMEN1KMT2AALDH1A1 | |
| SCHEMBL4620316 | 0.75 | PLA2G2A (0.47) | PDE10A | |
| SCHEMBL2614815 | 0.72 | KDM4E (0.47) | PDE10AKCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL4818109 | 0.70 | BACE1 (0.52) | BACE1MEN1KMT2AALDH1A1BCHE | |
| SCHEMBL4820714 | 0.70 | BACE1 (0.52) | BACE1MEN1KMT2AALDH1A1BCHE | |
| SCHEMBL1136269 | 0.70 | ALDH1A1 (0.59) | HRH4MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL5989887 | 0.70 | ALDH1A1 (0.66) | HRH4MEN1KMT2AALDH1A1 | |
| SCHEMBL5088569 | 0.69 | DHODH (0.45) | PDE10AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4075343-A | Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof | PFIZER INC. (US) | 1978-02-21 | — | — | US | disclosed |