SCHEMBL11620913

SCHEMBL11620913

COc1nn(-c2cccc(Cl)c2Cl)c(=O)o1

nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 7/20 0.50
ABHD16A O95870 2/20 0.50
FAAH O00519 7/20 0.49
P2RX7 Q99572 3/20 0.41
ABHD6 Q9BV23 1/20 0.40
LPL P06858 1/20 0.40
LIPC P11150 1/20 0.40
LIPE Q05469 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11618467 0.88 FAAH (0.55) MGLLABHD16AFAAH
SCHEMBL11621778 0.87 ABHD16A (0.52) MGLLABHD16AFAAHABHD6LPL
SCHEMBL11618257 0.86 MEN1 (0.44) MGLLABHD16AFAAHP2RX7
SCHEMBL11074790 0.80 MGLL (0.45) MGLLABHD16AFAAHABHD6
SCHEMBL74675 0.78 ABHD16A (0.57) MGLLABHD16AFAAH
SCHEMBL11619856 0.77 MGLL (0.50) MGLLABHD16AFAAHLIPCLIPE
SCHEMBL11618056 0.77 MGLL (0.50) MGLLABHD16AFAAHP2RX7LIPC
SCHEMBL11620519 0.77 FAAH (0.55) MGLLABHD16AFAAH
SCHEMBL11623485 0.77 FAAH (0.55) MGLLABHD16AFAAH
SCHEMBL2237059 0.77 ABHD16A (0.60) MGLLABHD16AFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4076824-A Anthelmintic oxadiazolinone derivatives RHONE-POULENC INDUSTRIES (FR) 1978-02-28 US claimed
US-4076824-A Anthelmintic oxadiazolinone derivatives RHONE-POULENC INDUSTRIES (FR) 1978-02-28 US disclosed