Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630603 | 0.79 | — | — | |
| SCHEMBL2144679 | 0.79 | — | — | |
| SCHEMBL1623564 | 0.70 | — | — | |
| SCHEMBL157430 | 0.70 | — | — | |
| SCHEMBL6594792 | 0.67 | — | — | |
| SCHEMBL4121654 | 0.67 | — | — | |
| SCHEMBL449280 | 0.65 | HTR2C (0.31) | — | |
| SCHEMBL1374665 | 0.65 | — | — | |
| SCHEMBL21267 | 0.65 | — | — | |
| SCHEMBL3922537 | 0.64 | MAOA (0.42) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148551-B2 | Tricyclic aromatics and liquid-crystalline medium | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2012-04-03 | — | — | US | disclosed |
| US-8029696-B2 | Fused naphthalenes | MERCK PATENT GMBH (DE) | 2011-10-04 | — | — | US | disclosed |
| EP-2044172-B1 | FUSED NAPHTHALENES | MERCK PATENT GMBH (DE) | 2011-06-22 | — | — | EP | disclosed |
| US-20110034469-A1 | Heterocyclic Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-10 | — | — | US | disclosed |
| WO-2011016576-A1 | ALANINE DERIVATIVES AS INHIBITORS OF APOPTOSIS PROTEINS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-10 | — | — | WO | disclosed |
| US-20100059711-A1 | FUSED NAPHTHALENES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-03-11 | — | — | US | disclosed |
| US-20090131689-A1 | TRICYCLIC AROMATICS AND LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2009-05-21 | — | — | US | disclosed |
| US-4783372-A | RADIATION SENSITIVE POLYIMIDES FOR PROTECTIVE COATINGS AND PHOTOGRAPHIC RELIEF IMAGES | CIBA-GEIGY CORPORATION (US) | 1988-11-08 | — | — | US | disclosed |
| US-4680195-A | POLYIMIDES WITH AROMATIC KETONE GROUPS, RELIEF IMAGES | CIBA-GEIGY CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034469-A1 | Heterocyclic Compound | BIRC5, XIAP, BIRC2 | TSHR 3703/4885 |
| US-20090131689-A1 | TRICYCLIC AROMATICS AND LIQUID-CRYSTALLINE MEDIUM | CHRM1, C1S, CHRM2 | TSHR 959/4885 |
| US-20100059711-A1 | FUSED NAPHTHALENES | CCNE2, CCNE1, F12 | TSHR 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.