Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11460905 | 0.90 | GAA (0.46) | KDM4EPOLBNPSR1LMNATSHR | |
| SCHEMBL11626066 | 0.89 | POLB (0.41) | KDM4EPOLBNPSR1LMNATSHR | |
| SCHEMBL11003097 | 0.87 | KMT2A (0.39) | KDM4EPOLBNPSR1LMNATSHR | |
| SCHEMBL11624146 | 0.84 | TSHR (0.40) | KDM4EPOLBLMNATSHRALDH1A1 | |
| SCHEMBL11628340 | 0.84 | MAPT (0.39) | KDM4EPOLBNPSR1LMNATSHR | |
| SCHEMBL11381545 | 0.83 | POLB (0.39) | KDM4EPOLBLMNATSHRALDH1A1 | |
| SCHEMBL11381103 | 0.82 | KCNA5 (0.40) | KDM4EPOLBLMNATSHRALDH1A1 | |
| SCHEMBL11627896 | 0.81 | TSHR (0.40) | KDM4EPOLBLMNATSHRALDH1A1 | |
| SCHEMBL11007676 | 0.81 | ALDH1A1 (0.40) | KDM4EPOLBLMNATSHRALDH1A1 | |
| SCHEMBL11375095 | 0.78 | CYP3A4 (0.39) | KDM4EPOLBNPSR1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4112095-A | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1978-09-05 | — | — | US | disclosed |