Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11624146 | 0.91 | TSHR (0.40) | MAPTRAB9AGAALMNATSHR | |
| SCHEMBL11460905 | 0.90 | GAA (0.46) | GAALMNATSHRPOLBALDH1A1 | |
| SCHEMBL11625289 | 0.84 | KDM4E (0.43) | MAPTRAB9AGAALMNATSHR | |
| SCHEMBL11003097 | 0.83 | KMT2A (0.39) | MAPTRAB9ANPC1TDP1GAA | |
| SCHEMBL11381103 | 0.82 | KCNA5 (0.40) | MAPTTDP1GAALMNATSHR | |
| SCHEMBL11626066 | 0.81 | POLB (0.41) | MAPTGAALMNATSHRPOLB | |
| SCHEMBL11381545 | 0.80 | POLB (0.39) | MAPTRAB9ATDP1GAALMNA | |
| SCHEMBL11007676 | 0.79 | ALDH1A1 (0.40) | MAPTRAB9ALMNATSHRPOLB | |
| SCHEMBL11627896 | 0.78 | TSHR (0.40) | RAB9ANPC1GAALMNATSHR | |
| SCHEMBL11375095 | 0.77 | CYP3A4 (0.39) | RAB9AGAALMNATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4112095-A | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1978-09-05 | — | — | US | disclosed |