Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL140565 | 0.88 | SYK (0.46) | PDK1PDK2PDK3PDK4SYK | |
| SCHEMBL25762545 | 0.87 | SYK (0.48) | PDK1PDK2PDK3PDK4SYK | |
| SCHEMBL23826487 | 0.85 | PDK1 (0.49) | PDK1PDK2PDK3PDK4SYK | |
| SCHEMBL30511007 | 0.83 | OPRD1 (0.49) | SYKCTSL | |
| SCHEMBL12496208 | 0.82 | FKBP1A (0.52) | SYKCTSL | |
| SCHEMBL115134 | 0.81 | SMN1; SMN2 (0.52) | HTR2C | |
| SCHEMBL12814239 | 0.81 | HTT (0.44) | PDK1PDK2PDK3PDK4SYK | |
| SCHEMBL2185018 | 0.81 | KMT2A (0.48) | PDK1PDK2PDK3PDK4DRD2 | |
| SCHEMBL5351275 | 0.81 | KDM4E (0.62) | DRD2HTT | |
| SCHEMBL30452743 | 0.81 | MEN1 (0.46) | PDK1PDK2PDK3PDK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | RECQL, BLVRB, NQO2 | PDK1 3211/4885PDK2 3126/4885PDK3 2908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.