Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | HTR7 | P34969 | 8/20 | 0.55 |
| ▸ | HTR1A | P08908 | 7/20 | 0.55 |
| ▸ | HTR2A | P28223 | 7/20 | 0.55 |
| ▸ | HTR6 | P50406 | 7/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HEXA | P06865 | 2/20 | 0.52 |
| ▸ | HEXB | P07686 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11807499 | 0.99 | DRD2 (0.57) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11804225 | 0.99 | DRD2 (0.57) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11811290 | 0.98 | KDM4E (0.55) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11628444 | 0.93 | RAD52 (0.58) | MEN1KMT2AHEXAHEXBKDM4E | |
| SCHEMBL7986618 | 0.90 | SIGMAR1 (0.60) | DRD2HTR1ADRD3SIGMAR1 | |
| SCHEMBL11808504 | 0.90 | CCR3 (0.56) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11814231 | 0.87 | DRD2 (0.49) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11803485 | 0.86 | DRD2 (0.49) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11804698 | 0.86 | HTR1A (0.56) | DRD2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11811302 | 0.85 | MAPK1 (0.56) | DRD2HTR7HTR1AHTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | claimed |
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |
| US-3935227-A | ANTIDEPRESSANTS, ANTIANXIETY, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |