Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11633966 | 0.91 | HTR1A (0.56) | HTR1ASIGMAR1L3MBTL1PARP1 | |
| SCHEMBL11748179 | 0.87 | HTR1A (0.46) | HTR1ASIGMAR1L3MBTL1HTR2AHTR7 | |
| SCHEMBL11633559 | 0.87 | HTR1A (0.42) | HTR1ASIGMAR1L3MBTL1KDM4EMAPT | |
| SCHEMBL11632573 | 0.87 | HTR1A (0.49) | HTR1ASIGMAR1L3MBTL1HTR7PARP1 | |
| SCHEMBL11632855 | 0.86 | HTR7 (0.53) | HTR1AL3MBTL1HTR2AHTR7HTR6 | |
| SCHEMBL11629570 | 0.85 | L3MBTL1 (0.41) | HTR1AL3MBTL1KDM4EALDH1A1LMNA | |
| SCHEMBL11632426 | 0.85 | L3MBTL1 (0.47) | HTR1AL3MBTL1ALDH1A1DRD2 | |
| SCHEMBL11632779 | 0.85 | HTR1A (0.50) | HTR1ASIGMAR1HTR7PARP1 | |
| SCHEMBL11633300 | 0.85 | HTR1A (0.50) | HTR1ASIGMAR1HTR7PARP1 | |
| SCHEMBL11632713 | 0.85 | L3MBTL1 (0.47) | HTR1ASIGMAR1L3MBTL1HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |