Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3559428 | 0.81 | CYP1A2 (0.46) | LDHAALDH1A1GAACYP1A2CYP2C9 | |
| SCHEMBL28032996 | 0.80 | PPARG (0.54) | PPARGPPARA | |
| SCHEMBL25564630 | 0.80 | LDHA (0.46) | LDHAALDH1A1TDP1GAAGFER | |
| SCHEMBL28861196 | 0.79 | MAOB (0.48) | ALDH1A1CYP3A4TSHRKMT2APPARG | |
| SCHEMBL3209492 | 0.78 | PARP10 (0.42) | PARP10LDHAALDH1A1TDP1CYP3A4 | |
| SCHEMBL6764389 | 0.77 | LMNA (0.50) | ALDH1A1TDP1CYP3A4TSHRMAOA | |
| SCHEMBL655457 | 0.76 | CYP1A2 (0.65) | PARP10ALDH1A1TDP1GAACYP1A2 | |
| SCHEMBL28584562 | 0.76 | CYP1A2 (0.65) | PARP10ALDH1A1TDP1GAACYP1A2 | |
| SCHEMBL5277876 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1TDP1GAAALOX15KMT2A | |
| SCHEMBL11587416 | 0.74 | PPARG (0.41) | PARP10LDHAALDH1A1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464634-B1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2016-11-30 | — | — | EP | disclosed |
| US-8933227-B2 | Selective synthesis of functionalized pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-01-13 | — | — | US | disclosed |
| US-20140213787-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-31 | — | — | US | disclosed |
| US-8729265-B2 | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-20 | — | — | US | disclosed |
| US-20120172596-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-05 | — | — | US | disclosed |
| EP-2464634-A1 | REGIOSELECTIVE PREPARATION OF 2 -AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2012-06-20 | — | — | EP | disclosed |
| EP-2464633-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2012-06-20 | — | — | EP | disclosed |
| US-20110190499-A1 | SELECTIVE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-04 | — | — | US | disclosed |
| WO-2011018517-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-02-17 | — | — | WO | disclosed |
| WO-2011018518-A1 | REGIOSELECTIVE PREPARATION OF 2 -AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190499-A1 | SELECTIVE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES | DPYD, TYMS, UMPS | PARP10 278/4885LDHA 4313/4885ALDH1A1 727/4885 |
| US-20140213787-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | DPYD, CYP3A5, PAICS | PARP10 629/4885LDHA 3920/4885ALDH1A1 172/4885 |
| US-20120172596-A1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | DPYD, HRH2, TYMS | PARP10 1123/4885LDHA 3209/4885ALDH1A1 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.