SCHEMBL11634591

SCHEMBL11634591

c1ccc2c(c1)nc1n2C(C2CCCCC2)CCCC1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.46
OPRM1 P35372 14/20 0.41
OPRK1 P41145 14/20 0.41
OGFRL1 Q5TC84 13/20 0.41
OPRD1 P41143 13/20 0.41
PRKACA P17612 2/20 0.41
RPS6KB1 P23443 2/20 0.41
GSK3B P49841 2/20 0.41
ROCK1 Q13464 2/20 0.41
OPRL1 P41146 3/20 0.41
LCK P06239 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9915108 0.76 TP53 (0.43) TP53OPRM1OPRK1OGFRL1OPRD1
SCHEMBL18150997 0.76 ACHE (0.36) TP53OPRM1OPRK1OGFRL1OPRD1
SCHEMBL18148654 0.72 CYP11B2 (0.39) TP53OPRM1OPRK1OGFRL1OPRD1
SCHEMBL9261907 0.72 SMN1; SMN2 (0.43) TP53OPRM1OPRK1OGFRL1OPRD1
SCHEMBL5800826 0.72 TP53 (0.42) TP53OPRM1OPRK1OGFRL1OPRD1
SCHEMBL10830714 0.70 MEN1 (0.62) TP53MEN1KMT2AHDAC6
SCHEMBL29794895 0.70 KDM4E (0.45) TP53MEN1KMT2A
Hydrochloric Acid SCHEMBL11644774 0.69 MEN1 (0.60) TP53MEN1KMT2AHDAC6
SCHEMBL840083 0.68 MEN1 (0.59) TP53MEN1KMT2AHDAC6
SCHEMBL21311255 0.68 OPRM1 (0.59) TP53OPRM1OPRK1OGFRL1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4104194-A 1,2-FUSED 5- OR 6-MEMBERED 1,3-DINITROGEN HETEROCYCLIC COMPOUNDS AS ANTICORROSION AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1978-08-01 US claimed
US-4104194-A 1,2-FUSED 5- OR 6-MEMBERED 1,3-DINITROGEN HETEROCYCLIC COMPOUNDS AS ANTICORROSION AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1978-08-01 US disclosed
US-4048174-A ANTI-CORROSION AGENTS BAYER AKTIENGESELLSCHAFT (DT) 1977-09-13 US disclosed