Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.45 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | MC3R | P41968 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 1/20 | 0.45 |
| ▸ | PTAFR | P25105 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11824480 | 0.89 | LMNA (0.53) | OPRK1PDE4DLMNAHPGDCHRM1 | |
| SCHEMBL11824471 | 0.89 | LMNA (0.53) | OPRK1PDE4DLMNAHPGDCHRM1 | |
| SCHEMBL11826370 | 0.82 | LMNA (0.61) | OPRK1PDE4DLMNAHPGDCHRM1 | |
| Clonazepam SCHEMBL14576992 | 0.81 | GABRA1 (0.63) | OPRK1PDE4DLMNAHPGDCHRM1 | |
| SCHEMBL11822866 | 0.81 | LMNA (0.62) | OPRK1PDE4DLMNAHPGDCHRM1 | |
| Estazolam SCHEMBL29357458 | 0.80 | OPRK1 (1.00) | OPRK1PDE4DLMNAHPGDGABRA1 | |
| Estazolam SCHEMBL28766 | 0.80 | OPRK1 (1.00) | OPRK1PDE4DLMNAHPGDGABRA1 | |
| SCHEMBL11108528 | 0.80 | OPRK1 (0.74) | OPRK1PDE4DLMNAHPGDCHRM1 | |
| SCHEMBL6060113 | 0.79 | OPRK1 (0.72) | OPRK1PDE4DLMNAHPGDGABRA1 | |
| SCHEMBL7324713 | 0.79 | GABRA1 (0.67) | OPRK1PDE4DLMNAHPGDCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4102881-A | REACTING 2-AMINOBENZOPHENONES WITH ALKYL ORTHO-HALO-ACETATE THEN WITH AN ALKALI METAL AZIDE, SUBJECTING TO REDUCTIVE RING CLOSURE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1978-07-25 | — | — | US | disclosed |