Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MARS1 | P56192 | 3/20 | 0.48 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117516 | 0.90 | SMN1; SMN2 (0.60) | SMN1; SMN2TDP1POLBMAPTMARS1 | |
| SCHEMBL3434175 | 0.82 | GRN (0.57) | SMN1; SMN2TDP1POLBMAPTMARS1 | |
| SCHEMBL5809543 | 0.74 | SMYD3 (0.57) | SMN1; SMN2TDP1POLBMAPTGRN | |
| SCHEMBL27687138 | 0.74 | SMN1; SMN2 (0.69) | SMN1; SMN2TDP1POLBMAPTMARS1 | |
| SCHEMBL13586959 | 0.73 | MEN1 (0.71) | SMN1; SMN2TDP1POLBMAPTTP53 | |
| SCHEMBL27687135 | 0.72 | MARS1 (0.65) | SMN1; SMN2TDP1POLBMAPTMARS1 | |
| SCHEMBL4689814 | 0.71 | GRN (0.64) | SMN1; SMN2TDP1POLBMAPTMARS1 | |
| SCHEMBL13219146 | 0.71 | GRN (0.82) | MAPTGRNSORT1CYP1A2CYP2D6 | |
| SCHEMBL8589911 | 0.70 | SMN1; SMN2 (0.54) | SMN1; SMN2TDP1POLBMAPTMARS1 | |
| SCHEMBL27706437 | 0.70 | SMN1; SMN2 (0.63) | SMN1; SMN2TDP1POLBMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | AARS1, GARS1, TRMT1 | SMN1; SMN2 3128/4885TDP1 1706/4885POLB 2510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.