Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | STAT3 | P40763 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GRN | P28799 | 2/20 | 0.56 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.56 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27687138 | 0.91 | SMN1; SMN2 (0.69) | MARS1SMN1; SMN2POLBTDP1MAPT | |
| SCHEMBL27706388 | 0.88 | GRN (0.56) | MARS1SMN1; SMN2POLBTDP1MAPT | |
| SCHEMBL27706390 | 0.87 | MAPT (0.56) | MARS1SMN1; SMN2POLBTDP1MAPT | |
| SCHEMBL4689814 | 0.84 | GRN (0.64) | MARS1SMN1; SMN2POLBTDP1MAPT | |
| SCHEMBL8589911 | 0.84 | SMN1; SMN2 (0.54) | MARS1SMN1; SMN2POLBTDP1MAPT | |
| SCHEMBL7901219 | 0.83 | MAPT (0.59) | MARS1SMN1; SMN2POLBTDP1MAPT | |
| SCHEMBL8367181 | 0.83 | MARS1 (0.65) | MARS1SMN1; SMN2MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8364783 | 0.82 | MARS1 (0.64) | MARS1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL117500 | 0.80 | MARS1 (1.00) | MARS1SMN1; SMN2POLBTDP1 | |
| SCHEMBL117660 | 0.80 | MARS1 (1.00) | MARS1SMN1; SMN2POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102274214-B | Medicinal use of (E)-N-furanylmethylene-1-benzyl-3-(4-chlorphenyl)-1H-pyrazol-5-carbohydrazide | UNIV SHANDONG | 2013-07-10 | — | — | CN | disclosed |
| CN-102274214-A | Medicinal use of (E)-N-furanylmethylene-1-benzyl-3-(4-chlorphenyl)-1H-pyrazol-5-carbohydrazide | — | 2011-12-14 | — | — | CN | disclosed |
| CN-101121711-A | Pyrazolcarbazone derivatives and application thereof | UNIV SHANDONG (CN) | 2008-02-13 | — | — | CN | disclosed |
| CN-101085758-A | 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivative, preparation method and application thereof | UNIV SHANDONG (CN) | 2007-12-12 | — | — | CN | disclosed |