Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CAD | P27708 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196155 | 0.80 | ALDH1A1 (0.45) | ALDH1A1LMNAHPGDMAPTCYP1A2 | |
| SCHEMBL1579478 | 0.79 | — | — | |
| SCHEMBL11576363 | 0.79 | — | — | |
| SCHEMBL8196369 | 0.79 | — | — | |
| SCHEMBL14598243 | 0.77 | ALOX15 (0.44) | ALOX15GAAMGAMSIMGAM2 | |
| SCHEMBL4427438 | 0.76 | — | — | |
| SCHEMBL1070748 | 0.74 | NPC1 (0.42) | ALOX15GAAMGAMSIMGAM2 | |
| SCHEMBL22941490 | 0.72 | ALOX15 (0.44) | ALOX15GAAMGAMSIMGAM2 | |
| SCHEMBL21780318 | 0.72 | ALOX15 (0.44) | ALOX15GAAMGAMSIMGAM2 | |
| SCHEMBL11713228 | 0.72 | ALOX15 (0.44) | ALOX15GAAMGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4129657-A | Imidazole guanidines and use as inhibitors of histamine activity | SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-12-12 | — | — | US | disclosed |