Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11646378 | 0.90 | MTNR1A (0.43) | HTR1BRECQLALDH1A1HTR1DL3MBTL1 | |
| Maleic Acid SCHEMBL11646373 | 0.90 | MTNR1A (0.43) | HTR1BRECQLALDH1A1HTR1DL3MBTL1 | |
| SCHEMBL11650045 | 0.83 | RECQL (0.47) | HTR1BRECQLALDH1A1HTR1DKCNA3 | |
| Hydrochloric Acid SCHEMBL11653181 | 0.82 | RECQL (0.46) | HTR1BRECQLALDH1A1HTR1DKCNA3 | |
| SCHEMBL11655739 | 0.81 | SIGMAR1 (0.47) | HTR1BRECQLALDH1A1HTR1DL3MBTL1 | |
| SCHEMBL3570361 | 0.80 | TDP1 (0.48) | RECQLALDH1A1KCNA3L3MBTL1MTNR1A | |
| Acetic Acid SCHEMBL11645576 | 0.80 | MTNR1A (0.54) | RECQLALDH1A1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL11654648 | 0.79 | ALDH1A1 (0.46) | RECQLALDH1A1KCNA3L3MBTL1MTNR1A | |
| SCHEMBL11653113 | 0.79 | LTA4H (0.49) | HTR1BRECQLALDH1A1HTR1DL3MBTL1 | |
| SCHEMBL24741070 | 0.77 | ALDH1A1 (0.55) | HTR1BRECQLALDH1A1HTR1DKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4071552-A | Aryloxy aminobutanols, their preparation and use thereof | AYERST MCKENNA AND HARRISON LTD. (CA) | 1978-01-31 | — | — | US | claimed |
| US-4131745-A | ANTIDEPRESSANT | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1978-12-26 | — | — | US | disclosed |
| US-4118511-A | Aryloxy aminobutanols for alleviating symptoms of depression | AYERST, MCKENNA & HARRISON LIMITED (CA) | 1978-10-03 | — | — | US | disclosed |
| US-4071552-A | Aryloxy aminobutanols, their preparation and use thereof | AYERST MCKENNA AND HARRISON LTD. (CA) | 1978-01-31 | — | — | US | disclosed |