Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794422 | 0.79 | LMNA (0.40) | FYNALDH1A1MEN1KMT2A | |
| SCHEMBL29745025 | 0.75 | NOS3 (0.52) | NOS3NOS2NOS1DYRK1AALDH1A1 | |
| SCHEMBL2954177 | 0.75 | NOS3 (0.52) | NOS3NOS2NOS1DYRK1AALDH1A1 | |
| SCHEMBL29186569 | 0.74 | EGFR (0.52) | DDR2KDRNPC1PDGFRBPDGFRA | |
| SCHEMBL30051292 | 0.74 | EGFR (0.52) | DDR2KDRNPC1PDGFRBPDGFRA | |
| SCHEMBL13603220 | 0.73 | NOS3 (0.47) | NOS3NOS2KDRALDH1A1MEN1 | |
| SCHEMBL1146056 | 0.73 | ADORA2A (0.42) | NOS3NOS2NOS1CYP3A4CYP1A2 | |
| SCHEMBL1165314 | 0.72 | FYN (0.52) | FYNNOS3NOS2NOS1PRKACA | |
| SCHEMBL12616282 | 0.72 | ALDH1A1 (0.55) | NOS3NOS2ALDH1A1MEN1KMT2A | |
| SCHEMBL116606 | 0.71 | ALDH1A1 (0.69) | CYP3A4CYP1A1CYP1A2CYP2E1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013207-B1 | IMIDAZO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS CANCER THERAPEUTIC COMPOUNDS | CANCER REC TECH LTD (GB) | 2012-04-25 | — | — | EP | disclosed |