Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11650363 | 0.92 | LMNA (0.42) | ELANECYP19A1HRH4KMT2AMEN1 | |
| SCHEMBL11647576 | 0.87 | CYP2A6 (0.39) | MAPK1KDM4EMAOBSETD7MAOA | |
| SCHEMBL11649728 | 0.86 | SETD7 (0.33) | MAPK1KDM4ESETD7 | |
| SCHEMBL11648575 | 0.83 | MAPK1 (0.43) | CYP19A1HRH4KMT2AMEN1MAPK1 | |
| SCHEMBL11654908 | 0.83 | MAPK1 (0.43) | CYP19A1HRH4KMT2AMEN1MAPK1 | |
| SCHEMBL11652061 | 0.77 | METAP1 (0.43) | ELANEGAAKMT2AMEN1CASP6 | |
| SCHEMBL11648705 | 0.75 | NR1H2 (0.38) | MAOA | |
| SCHEMBL11655289 | 0.72 | HTR1A (0.39) | MAPK1 | |
| SCHEMBL19885347 | 0.71 | ELANE (0.45) | ELANECYP19A1HRH4GAAKMT2A | |
| SCHEMBL17589604 | 0.70 | SETD7 (0.40) | ELANECYP19A1HRH4GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4125718-A | Amino-substituted tetracyclic compounds | AKZONA INCORPORATED (US) | 1978-11-14 | — | — | US | disclosed |
| US-4062840-A | Amino-substituted 1,2,3,4-tetrahydro-9H-tribenzo[b,d,f]azepines | AKZONA INCORPORATED (US) | 1977-12-13 | — | — | US | disclosed |
| US-3950425-A | Amino-substituted tetracyclic compounds | AKZONA INCORPORATED (US) | 1976-04-13 | — | — | US | disclosed |