Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.42 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.42 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.42 |
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.42 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.42 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.42 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.42 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.42 |
| ▸ | OPRK1 known ✓ | P41145 | 2/20 | 0.42 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.42 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.42 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.42 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.42 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701 | 0.93 | CHRM2 (0.48) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Hydrochloric Acid SCHEMBL41905 | 0.92 | LMNA (0.49) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Hydrochloric Acid SCHEMBL28987388 | 0.92 | LMNA (0.49) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Oxalic Acid SCHEMBL28012360 | 0.91 | CYP2D6 (0.42) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL29045196 | 0.90 | LMNA (0.37) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Cyclohexane SCHEMBL28903496 | 0.90 | CHRM2 (0.45) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Propionic Acid SCHEMBL599320 | 0.89 | OPRM1 (0.42) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Fumaric Acid SCHEMBL2118137 | 0.88 | CYP2D6 (0.40) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL18779843 | 0.74 | MAPT (0.37) | ALOX15HSD17B10ALDH1A1LMNAKMT2A | |
| SCHEMBL19759877 | 0.74 | ALDH1A1 (0.33) | PTGS1ALDH1A1SMN1; SMN2MAOAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111943910-B | Dioxopropazine hydrochloride and preparation method thereof | 上海金不换兰考制药有限公司 | 2022-09-09 | — | — | CN | claimed |
| CN-111943910-A | Dioxopropazine hydrochloride and preparation method thereof | 河南优凯制药有限公司 | 2020-11-17 | — | — | CN | claimed |
| CN-111943910-B | Dioxopropazine hydrochloride and preparation method thereof | 上海金不换兰考制药有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-111943910-A | Dioxopropazine hydrochloride and preparation method thereof | 河南优凯制药有限公司 | 2020-11-17 | — | — | CN | disclosed |
| US-4071620-A | PROMETHAZINE WITH MONOTHIOGLYCEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1978-01-31 | — | — | US | disclosed |