SCHEMBL11657252

SCHEMBL11657252

CC(=O)c1cn(C)c2cc(-c3ccncc3)ccc2c1=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 4/20 0.58
CAPN1 P07384 9/20 0.53
CTSL P07711 2/20 0.52
CTSB P07858 2/20 0.52
ROCK2 O75116 4/20 0.50
CDK1 P06493 4/20 0.50
PRKACA P17612 4/20 0.50
CDK2 P24941 4/20 0.50
CSNK1D P48730 4/20 0.50
GSK3A P49840 4/20 0.50
CDK5 Q00535 4/20 0.50
PRKCD Q05655 4/20 0.50
ROCK1 Q13464 4/20 0.50
CDC42BPA Q5VT25 4/20 0.50
DYRK3 O43781 3/20 0.50
RPS6KA5 O75582 3/20 0.50
PRKD3 O94806 3/20 0.50
MAP4K4 O95819 3/20 0.50
CLK2 P49760 3/20 0.50
GSK3B P49841 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10474583 0.90 CAPN1 (0.65) NR4A2CAPN1CTSLCTSBROCK2
SCHEMBL10474281 0.88 CAPN1 (0.66) NR4A2CAPN1CTSLCTSBROCK2
SCHEMBL11652572 0.84 ROCK2 (0.48) NR4A2CAPN1CTSLCTSBROCK2
SCHEMBL11655148 0.84 CAPN1 (0.50) NR4A2CAPN1CTSLCTSBROCK2
SCHEMBL11655207 0.81 NR1D1 (0.55) NR4A2CAPN1CTSLCTSBROCK2
SCHEMBL11659513 0.81 CNR1 (0.54)
SCHEMBL10475298 0.74 CAPN1 (0.59) NR4A2CAPN1CTSLCTSBROCK2
SCHEMBL21392031 0.73 NR4A2 (0.49) NR4A2CAPN1ROCK2CDK1PRKACA
Rosoxacin SCHEMBL135645 0.73 CAPN1 (0.61) CAPN1CTSLCTSBROCK2CDK1
Rosoxacin SCHEMBL29361483 0.73 CAPN1 (0.61) CAPN1CTSLCTSBROCK2CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4107167-A Alkyl α-[3-(pyridyl)-anilinomethylene]acetoacetates STERLING DRUG INC. (US) 1978-08-15 US disclosed