Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11654025 | 0.87 | ALDH1A1 (0.46) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL11657778 | 0.86 | LMNA (0.44) | SMN1; SMN2POLBRAB9ANPC1NPSR1 | |
| SCHEMBL11658272 | 0.85 | CYP2C9 (0.57) | SMN1; SMN2KDM4EPOLBAPEX1TDP1 | |
| SCHEMBL11652631 | 0.84 | MAPT (0.39) | SMN1; SMN2KDM4EPOLBAPEX1TDP1 | |
| SCHEMBL11652455 | 0.81 | PDE4B (0.51) | SMN1; SMN2KDM4ERAB9ANPC1MAPT | |
| SCHEMBL11655639 | 0.77 | POLB (0.57) | KDM4EPOLBNPC1ALDH1A1LMNA | |
| SCHEMBL27504219 | 0.74 | RAB9A (0.44) | SMN1; SMN2KDM4EPOLBAPEX1TDP1 | |
| SCHEMBL28524227 | 0.74 | RAB9A (0.64) | SMN1; SMN2KDM4EPOLBAPEX1TDP1 | |
| SCHEMBL11655985 | 0.73 | KDM4E (0.42) | SMN1; SMN2KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL20037334 | 0.73 | PDE4D (0.56) | SMN1; SMN2KDM4EPOLBAPEX1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4108982-A | DIURETICS, HYPOTENSIVE AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1978-08-22 | — | — | US | disclosed |