Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.35 |
| ▸ | KDM1A | O60341 | 7/20 | 0.35 |
| ▸ | MAOA | P21397 | 6/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628664 | 0.66 | CHRM1 (0.56) | MAOBKDM1AMAOACYP2C19SLC6A4 | |
| SCHEMBL5232783 | 0.64 | HDAC4 (0.41) | MAOBMAOAPOLBCYP3A4PARP1 | |
| SCHEMBL13093634 | 0.63 | SLC9A1 (0.45) | MAOBKDM1AMAOASLC9A1POLB | |
| SCHEMBL28571626 | 0.63 | SLC9A1 (0.53) | MAOBKDM1AMAOASLC9A1POLB | |
| SCHEMBL30788829 | 0.63 | SLC9A1 (0.53) | MAOBKDM1AMAOASLC9A1POLB | |
| SCHEMBL20960545 | 0.62 | KDM1A (0.35) | MAOBKDM1AMAOAL3MBTL1LMNA | |
| SCHEMBL20960573 | 0.62 | KDM1A (0.35) | MAOBKDM1AMAOAL3MBTL1LMNA | |
| SCHEMBL3704068 | 0.62 | AKR1C1 (0.38) | MAOBPOLBCYP3A4PARP1MAPT | |
| SCHEMBL307974 | 0.62 | KDM1A (0.48) | MAOBKDM1AMAOACYP2C19 | |
| SCHEMBL2722547 | 0.61 | AKR1C1 (0.57) | AKR1C1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4066764-A | 1,4-Dihydro-2H-isoquinoline derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-01-03 | — | — | US | disclosed |
| US-4049655-A | 1,4-Dihydro-2H-isoquinoline derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-09-20 | — | — | US | disclosed |
| US-3980655-A | Basically substituted 1,4-dihydro-2H-isoquinoline derivatives and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-09-14 | — | — | US | disclosed |